![]() ![]() ![]() Clinicians should be aware that while GI adverse reactions are relatively common with the usual use of amphetamine dextroamphetamine, excessive abdominal cramping, nausea, vomiting, or diarrhea may represent excessive dosage and toxicity. Complaints of xerostomia or dysgeusia may be limited by sucking sugarless hard candy, crushed ice, and drinking plenty of water or other fluids. Bowel ischemia has been reported during postmarketing use. Dysgeusia, constipation, diarrhea, and teeth grinding (bruxism) have also been reported with amphetamine use. Other GI adverse reactions include abdominal pain (11% to 14%) and xerostomia (2% to 4% of adolescents 35% of adults). Eating small, frequent meals or snacks may help limit appetite problems. Dyspepsia (2% to 4%), nausea (2% to 5%), and vomiting (2% to 7%) have also been reported. Higher doses were associated with greater weight loss within the initial 4 weeks of treatment. In a controlled trial of extended-release amphetamine dextroamphetamine in adolescents, the mean change in weight during the first 4 weeks of therapy was -1.1 pounds and -2.8 pounds, respectively for patients who received 10 mg and 20 mg daily. In clinical trials of extended-release amphetamine dextroamphetamine, weight loss occurred in 4% of children and 9% of adolescents. Weight loss is a dose-related adverse reaction commonly associated with stimulant use and is of particular concern in growing children and adolescents. ![]() Loss of appetite was reported in 22% of children and 36% of adolescents receiving extended-release amphetamine dextroamphetamine in clinical trials. The side effects may be more frequent or severe with the initial days of therapy.Īnorexia is one of the most common gastrointestinal (GI) adverse reactions associated with stimulant use. If swallowing is difficult, the capsule may be opened and the entire contents gently sprinkled on a spoonful of applesauce and swallowed immediately (do not store for future use).Īdverse side effects of amphetamine dextroamphetamine are frequent but usually mild to moderate in children with attention-deficit hyperactivity disorder (ADHD) at normally prescribed dosages. Swallow whole, do not crush, cut, or chew the capsule or capsule contents (beads). Administer dose once daily in the morning upon awakening consistently either with or without food. Do not divide the dose of a single capsule. Follow with a drink of water or other liquid. If swallowing is difficult, the capsule may be opened and the entire contents gently sprinkled on a spoonful of cool applesauce and swallowed immediately (do not store for future use). Administer dose once daily in the morning upon awakening. Subsequent doses during the day, if given, should be administered at least 6 hours before bedtime to avoid sleep interference. Administer the first dose of the day upon awakening. For storage information, see the specific product information within the How Supplied section. ![]()
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